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Thymoma stage

whims' playground 2016. 6. 28. 07:12
StageDefinition
IMacroscopically and microscopically completely encapsulated
IIAMicroscopic transcapsular invasion
IIBMacroscopic invasion into surrounding fatty tissue or grossly adherent to but not through mediastinal pleura or pericardium
IIIMacroscopic invasion into neighboring organs (ie, pericardium, great vessels, or lung)
IVAPleural or pericardial dissemination
IVBLymphogenous or hematogenous metastasis
WHO histologic classificationTypeHistologic description
ATumor in which foci having features of type A thymoma are admixed with foci rich in lymphocytes
 



B1



Tumor resembles normal functional thymus; combines large expanses having an appearance practically indistinguishable from that of normal thymic cortex with areas resembling thymic medulla
 



B2



Tumor in which neoplastic epithelial component appears as scattered plump cells with vesicular nuclei and distinct nucleoli among a heavy population of lymphocytes; perivascular spaces are common and sometimes very prominent; a perivascular arrangement of tumor cells resulting in a palisading effect may be seen.
 



B3



Thymoma predominantly composed of epithelial cells having a round or polygonal shape and exhibiting no or mild atypia; they are admixed with a mild component of lymphocytes, resulting in a sheetlike growth of the neoplastic epithelial cells
 



C



Thymic tumor exhibiting clear-cut cytologic atypia and a set of cytoarchitectural features no longer specific to the thymus, but rather analogous to those seen in carcinomas of the other organs; type C thymomas lack immature lymphocytes; whatever lymphocytes may be present are mature and usually admixed with plasma cells


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